Executive Director, GCS Immunology — TCE

Job Description General Summary: The Executive Director, Global Commercial Strategy (GCS) Immunology - TCE will be the senior commercial leader for the T-cell engager programs within the Immunology vertical. The role will own the commercial strategy for where and how the TCE portfolio advances across Immunology, including potential use in gMG, lupus, systemic sclerosis (SSc), myositis, and other rare immunology indications. The Executive Director will co-lead the Immunology TCE Program Team with the Development Lead, guiding indication selection, program strategy, and key development and investment decisions. The role will also own disease strategy for SSc, myositis, and other rare immunology indications, while partnering with the relevant disease leads when TCE opportunities extend into areas such as gMG or lupus. Key Duties & Responsibilities - Co-lead the Immunology TCE Program Team with the Development Lead, setting the integrated strategy, priorities, and decision framework for the TCE portfolio. - Own the commercial strategy for where to take the TCE programs across Immunology, integrating disease attractiveness, biological rationale, unmet need, competitive context, development feasibility, and commercial potential. - Own disease strategy for SSc, myositis, and other rare immunology indications, building deep understanding of the markets and requirements for success. - Partner with the GCS disease leads for gMG, lupus, and other established areas when evaluating or advancing TCE opportunities within their diseases, ensuring clear disease and program accountabilities. - Lead indication prioritization and commercial assessments, including target populations, treatment pathways, target product profiles, differentiation, evidence needs, opportunity, forecasts, risks, and investment implications. - Shape development plans and lead commercial development activities, including market research, forecasting, competitive intelligence, scenario planning, evidence requirements, and business cases. - Develop the global commercialization strategy for the Immunology TCE portfolio, including indication sequencing, positioning, evidence generation, market development, and resource priorities. - Lead global launch preparation for TCE indications that advance, including critical success factors, regional alignment, readiness milestones, and cross-functional execution. - Partner across Development, Medical, Regulatory, Value & Access, Finance, and regional Commercial teams to ensure decisions reflect a globally aligned Commercial perspective. - Communicate clear recommendations to senior leaders and governance bodies, identifying key uncertainties, trade-offs, risks, and actions required. - Build and lead a high-performing TCE commercial team as the portfolio advances. Required Education Level - Minimum of a Bachelor’s degree in business, marketing, life sciences, healthcare, or a related field. - Advanced degree such as an MBA, M.S., Pharm.D., Ph.D., or M.D. preferred. Required Experience - Extensive biopharmaceutical commercial experience, including global commercial strategy, new product planning, or marketing leadership. - Demonstrated experience shaping early pipeline assets and translating market insight into indication selection, development strategy, evidence requirements, and investment decisions. - Strong experience leading cross-disease commercial assessments, forecasts, business cases, and scenario analyses under significant uncertainty. - Launch or development experience in specialty, rare disease, rheumatology, neurology, immunology, or other complex markets; direct Immunology experience strongly preferred. - Experience leading cross-functional teams in a matrixed environment; program-team leadership experience preferred. - Exceptional strategic thinking, analytical rigor, business judgment, communication, and influencing skills. - Proven people leadership and ability to build collaborative, high-performing teams. At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients. Pay Range: $260,600 - $390,800 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time. #LI-Hybrid Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com