Scientist, Rare Disease Biology

Career Category Research Job Description At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career. Scientist, Rare Disease Biology What you will do Let’s do this. Let’s change the world. In this vital role you will contribute to the discovery and advancement of innovative therapies for rare diseases by serving as a core member of multidisciplinary disease-focused research team. You will apply data-driven approaches to investigate disease mechanisms, evaluate novel therapeutic targets, and generate insights that inform portfolio decisions. This role offers the opportunity to work at the intersection of disease biology, human data, and emerging technologies within a highly collaborative and scientifically rigorous environment. Key responsibilities: - Independently, plan, design, execute, analyze, and interpret in vitro and ex vivo studies to elucidate disease mechanisms and evaluate therapeutic hypotheses. - Generate reproducible, high-quality experimental data to support target identification, validation, and progression of rare disease research programs. - Integrate experimental findings with published literature, human genetics, clinical observations, and other data sources to develop mechanistic insights and inform scientific decision-making. - Apply computational and data analysis tools to evaluate datasets, identify mechanistic relationships, and support target prioritization efforts. - Contribute to the development and implementation of innovative experimental approaches that improve scientific rigor, efficiency, and translational relevance. - Serve as an active member of disease-focused research teams, collaborating closely with disease biologists, computational scientists, translational researchers, and partner functions. - Participate in scientific discussions, target reviews, and portfolio evaluations by contributing data-driven insights and recommendations. - Support productive relationships with internal and external collaborators, including academic partners, foundations, and scientific experts when appropriate. - Present scientific findings and recommendations to project teams, governance forums, and departmental meetings. - Maintain accurate documentation and contribute to organizational knowledge-sharing efforts. - Embrace and contribute to a culture of scientific curiosity, collaboration, continuous learning, and operational excellence. What we expect of you We are all different, yet we all use our unique contributions to serve patients. The professional we seek is a Scientist with the following qualifications: Basic Qualifications - PhD in Immunology, Cell Biology, Molecular Biology, Pharmacology, Biomedical Sciences, or related discipline OR - Master's degree and 2 years of scientific research experience OR - Bachelor's degree and 4 years of scientific research experience Preferred Qualifications - Experience in gout or related therapeutic areas. - Experience in enzyme biology or the discovery and development of enzyme-based therapeutics, including enzyme replacement therapies. - Demonstrated ability to independently design, execute, and troubleshoot cell-based, molecular, and biochemical experiments. - Experience developing or applying disease-relevant cellular systems, including primary cells, patient-derived samples, or advanced in vitro and ex vivo models - Strong quantitative and data-interpretation skills, including the ability to integrate experimental results with genetics, omics, clinical data, or published evidence. - Experience working with computational or bioinformatics partners to generate and test biological hypotheses. - Familiarity with AI-assisted tools for scientific analysis, literature synthesis, or hypothesis generation. - Experience in biotechnology, pharmaceutical research, translational research, or multidisciplinary drug-discovery teams. - Ability to balance scientific rigor with urgency and adaptability in a dynamic research environment including openness to changing evidence. - Demonstrated ability to work collaboratively in matrixed teams embracing teamwork, knowledge sharing, and continuous improvement. - Strong scientific communication skills with the ability to explain complex findings and their implications to diverse audiences. What you can expect of us As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way. The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications. In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include: - A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts - A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan - Stock-based long-term incentives - Award-winning time-off plans - Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies. Apply now and make a lasting impact with the Amgen team. careers.amgen.com In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information. Application deadline External/Internal postings: Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position. Internal only posting (or Pre-ID candidate): Amgen anticipates accepting applications until 1 week before the posting; however, we may continue accepting applications beyond this date if we do not receive a sufficient number of candidates. Sponsorship Sponsorship for this role is not guaranteed. As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease. Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. . Salary Range 115,393.45USD -156,120.55 USD